Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: George Quarles Away Manager: Chris Hatcher
| NCAAF | 2021/09/25 19:00 | East Tennessee State v Samford | L | 55-48 |
| NCAAF | 2021/02/20 18:00 | Samford v East Tennessee State | L | 17-24 |
| NCAAF | 2019/10/26 17:00 | East Tennessee State v Samford | W | 17-24 |
| NCAAF FCS | 2018/11/17 18:00 | Samford v East Tennessee State | W | 38-27 |
| NCAAF | 2017/11/11 20:00 | Samford v East Tennessee State | W | 42-7 |