Stadium: O'Brien Stadium Round: 1
Home Manager: Chris Wilkerson Away Manager: Tom Matukewicz
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | W | 15-38 |
| NCAAF | 2021/02/28 20:00 | Eastern Illinois v SE Missouri St | W | 7-47 |
| NCAAF | 2019/11/16 18:00 | SE Missouri St v Eastern Illinois | W | 26-12 |
| NCAAF FCS | 2018/11/17 19:00 | Eastern Illinois v SE Missouri St | W | 32-38 |
| NCAAF | 2017/09/23 23:00 | Eastern Illinois v SE Missouri St | L | 19-16 |
| NCAAF | 2022/11/05 22:00 | SE Missouri St v Tennessee State | W | 42-0 |
| NCAAF | 2022/10/29 18:00 | Eastern Kentucky v SE Missouri St | L | 28-23 |
| NCAAF | 2022/10/22 18:00 | SE Missouri St v Northwestern State | W | 51-16 |
| NCAAF | 2022/10/08 19:00 | Tennessee Tech v SE Missouri St | W | 20-34 |
| NCAAF | 2022/10/01 18:00 | SE Missouri St v Lindenwood | W | 49-28 |
| NCAAF | 2022/09/24 19:00 | Central Arkansas v SE Missouri St | W | 27-35 |
| NCAAF | 2022/09/17 19:00 | Nicholls State v SE Missouri St | W | 16-42 |
| NCAAF | 2022/09/10 23:00 | SE Missouri St v SO Illinois | W | 34-31 |
| NCAAF | 2022/11/06 00:00 | Eastern Illinois v McNeese State | L | 15-29 |
| NCAAF | 2022/10/29 19:00 | Tennessee Tech v Eastern Illinois | L | 20-17 |
| NCAAF | 2022/10/22 19:00 | Eastern Illinois v Tennessee State | L | 17-37 |
| NCAAF | 2022/10/15 19:00 | Lindenwood v Eastern Illinois | L | 37-34 |
| NCAAF | 2022/10/08 19:00 | Northwestern State v Eastern Illinois | W | 27-35 |
| NCAAF | 2022/09/24 21:00 | Eastern Illinois v Murray State | W | 35-21 |
| NCAAF | 2022/09/17 23:30 | Eastern Illinois v Illinois State | L | 7-35 |
| NCAAF | 2022/09/10 23:00 | Tennessee Chattanooga v Eastern Illinois | L | 38-20 |