Stadium: O'Brien Stadium Round: 1
Home Manager: Chris Wilkerson Away Manager: Tom Matukewicz
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | W | 15-38 |
| NCAAF | 2021/02/28 20:00 | Eastern Illinois v SE Missouri St | W | 7-47 |
| NCAAF | 2019/11/16 18:00 | SE Missouri St v Eastern Illinois | W | 26-12 |
| NCAAF FCS | 2018/11/17 19:00 | Eastern Illinois v SE Missouri St | W | 32-38 |
| NCAAF | 2017/09/23 23:00 | Eastern Illinois v SE Missouri St | L | 19-16 |