Eastern Illinois 35-21 Murray State 2022-09-24 21:00
Stadium: Roy Stewart Stadium Round: 1
Home Manager: Dean Hood Away Manager: Chris Wilkerson
Head to Head
| NCAAF | 2021/11/20 18:00 | Murray State v Eastern Illinois | L | 20-13 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | L | 6-22 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | L | 27-41 |
| NCAAF | 2019/10/05 18:00 | Eastern Illinois v Murray State | L | 17-24 |
| NCAAF | 2018/10/06 23:00 | Murray State v Eastern Illinois | L | 48-41 |
| NCAAF | 2017/10/14 20:00 | Murray State v Eastern Illinois | W | 24-27 |
Home History
| NCAAF | 2022/09/17 23:30 | Eastern Illinois v Illinois State | L | 7-35 |
| NCAAF | 2022/09/10 23:00 | Tennessee Chattanooga v Eastern Illinois | L | 38-20 |
| NCAAF | 2022/09/02 00:00 | Eastern Illinois v Northern Illinois | L | 27-34 |
| NCAAF | 2021/11/20 18:00 | Murray State v Eastern Illinois | L | 20-13 |
| NCAAF | 2021/11/06 19:00 | Eastern Illinois v Austin Peay | L | 26-42 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | L | 15-38 |
| NCAAF | 2021/10/23 19:00 | Tennessee State v Eastern Illinois | L | 28-0 |
| NCAAF | 2021/10/16 19:00 | Tennessee Martin v Eastern Illinois | L | 28-17 |
Away History
| NCAAF | 2022/09/17 18:00 | Murray State v Ball State | L | 0-31 |
| NCAAF | 2022/09/10 23:00 | Jacksonville State v Murray State | L | 34-3 |
| NCAAF | 2022/09/04 00:00 | Murray State v Texas Tech | L | 10-63 |
| NCAAF | 2021/11/20 18:00 | Murray State v Eastern Illinois | W | 20-13 |
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Murray State | W | 10-28 |
| NCAAF | 2021/11/06 18:00 | Tennessee Tech v Murray State | W | 27-32 |
| NCAAF | 2021/10/30 22:00 | Murray State v Tennessee State | L | 21-27 |
| NCAAF | 2021/10/23 19:00 | Austin Peay v Murray State | L | 47-6 |