[8] Mississippi State 6-30 Alabama [3] 2022-10-22 23:00
Stadium: Bryant-Denny Stadium Round: 1
Home Manager: Nick Saban Away Manager: Mike Leach
Head to Head
| NCAAF | 2021/10/16 23:00 | Alabama v Mississippi State | L | 49-9 |
| NCAAF | 2020/10/31 23:00 | Mississippi State v Alabama | L | 0-41 |
| NCAAF | 2019/11/16 17:00 | Alabama v Mississippi State | L | 38-7 |
| NCAAF | 2018/11/10 20:30 | Mississippi State v Alabama | L | 0-24 |
| NCAAF | 2017/11/12 00:00 | Alabama v Mississippi State | L | 31-24 |
| NCAAF | 2016/11/12 17:00 | Mississippi State v Alabama | L | 3-51 |
| NCAAF | 2015/11/14 20:30 | Mississippi State v Alabama | L | 6-31 |
| NCAAF | 2014/11/15 20:30 | Alabama v Mississippi State | L | 25-20 |
Home History
| NCAAF | 2022/10/15 23:30 | Mississippi State v Kentucky | L | 17-27 |
| NCAAF | 2022/10/08 16:00 | Arkansas v Mississippi State | W | 17-40 |
| NCAAF | 2022/10/01 20:00 | Texas A&M v Mississippi State | W | 24-42 |
| NCAAF | 2022/09/24 16:00 | Bowling Green v Mississippi State | W | 14-45 |
| NCAAF | 2022/09/17 22:00 | Mississippi State v LSU | L | 16-31 |
| NCAAF | 2022/09/11 03:00 | Mississippi State v Arizona | W | 39-17 |
| NCAAF | 2022/09/03 23:30 | Memphis v Mississippi State | W | 23-49 |
| NCAAF Bowl Games | 2021/12/28 23:45 | Texas Tech v Mississippi State | L | 34-7 |
Away History
| NCAAF | 2022/10/16 20:00 | Alabama v Arkansas Pine Bluff | W | 34-31 |
| NCAAF | 2022/10/15 19:30 | Alabama v Tennessee | L | 49-52 |
| NCAAF | 2022/10/09 00:00 | Texas A&M v Alabama | W | 20-24 |
| NCAAF | 2022/10/08 18:00 | Grambling State v Alabama | W | 31-37 |
| NCAAF | 2022/10/01 19:30 | Alabama v Arkansas | W | 49-26 |
| NCAAF | 2022/10/01 19:00 | Bethune Cookman v Alabama | W | 27-35 |
| NCAAF | 2022/09/24 23:30 | Vanderbilt v Alabama | W | 3-55 |
| NCAAF | 2022/09/24 22:00 | Alabama v Florida A&M | L | 25-38 |