[8] Mississippi State 6-30 Alabama [3] 2022-10-22 23:00
Stadium: Bryant-Denny Stadium Round: 1
Home Manager: Nick Saban Away Manager: Mike Leach
Head to Head
| NCAAF | 2021/10/16 23:00 | Alabama v Mississippi State | L | 49-9 |
| NCAAF | 2020/10/31 23:00 | Mississippi State v Alabama | L | 0-41 |
| NCAAF | 2019/11/16 17:00 | Alabama v Mississippi State | L | 38-7 |
| NCAAF | 2018/11/10 20:30 | Mississippi State v Alabama | L | 0-24 |
| NCAAF | 2017/11/12 00:00 | Alabama v Mississippi State | L | 31-24 |
| NCAAF | 2016/11/12 17:00 | Mississippi State v Alabama | L | 3-51 |
| NCAAF | 2015/11/14 20:30 | Mississippi State v Alabama | L | 6-31 |
| NCAAF | 2014/11/15 20:30 | Alabama v Mississippi State | L | 25-20 |
| NCAAF | 2012/10/27 12:00 | Alabama v Mississippi State | L | 38-7 |
| NCAAF | 2011/11/12 12:00 | Mississippi State v Alabama | L | 7-24 |
| NCAAF | 2010/11/13 12:00 | Alabama v Mississippi State | L | 30-10 |
| NCAAF | 2009/11/14 12:00 | Mississippi State v Alabama | L | 3-31 |
| NCAAF | 2008/11/15 12:00 | Alabama v Mississippi State | L | 32-7 |
| NCAAF | 2007/11/10 12:00 | Mississippi State v Alabama | W | 17-12 |
| NCAAF | 2006/11/04 12:00 | Alabama v Mississippi State | W | 16-24 |
| NCAAF | 2005/11/05 12:00 | Mississippi State v Alabama | L | 0-17 |
| NCAAF | 2004/11/06 12:00 | Alabama v Mississippi State | L | 30-14 |
| NCAAF | 2003/11/08 12:00 | Mississippi State v Alabama | L | 0-38 |
| NCAAF | 2002/11/09 12:00 | Alabama v Mississippi State | L | 28-14 |
| NCAAF | 2001/11/10 12:00 | Alabama v Mississippi State | L | 24-17 |
| NCAAF | 2000/11/11 12:00 | Mississippi State v Alabama | W | 29-7 |