[5] Iowa 10-54 Ohio State [1] 2022-10-22 16:00
Stadium: Ohio Stadium Round: 1
Home Manager: Ryan Day Away Manager: Kirk Ferentz
Head to Head
| NCAAF | 2017/11/04 19:30 | Ohio State v Iowa | W | 24-55 |
| NCAAF | 2010/11/20 12:00 | Iowa v Ohio State | L | 17-20 |
| NCAAF | 2009/11/14 12:00 | Ohio State v Iowa | L | 27-24 |
| NCAAF | 2006/09/30 12:00 | Iowa v Ohio State | L | 17-38 |
| NCAAF | 2005/09/24 12:00 | Ohio State v Iowa | L | 31-6 |
| NCAAF | 2004/10/16 12:00 | Iowa v Ohio State | W | 33-7 |
| NCAAF | 2003/10/18 12:00 | Ohio State v Iowa | L | 19-10 |
| NCAAF | 2000/10/21 12:00 | Iowa v Ohio State | L | 10-38 |
Home History
| NCAAF | 2022/10/08 23:30 | Iowa v Illinois | L | 6-9 |
| NCAAF | 2022/10/01 16:00 | Michigan v Iowa | L | 27-14 |
| NCAAF | 2022/09/24 23:00 | Iowa v Rutgers | W | 27-10 |
| NCAAF | 2022/09/17 23:30 | Nevada v Iowa | W | 0-27 |
| NCAAF | 2022/09/10 20:00 | Iowa State v Iowa | L | 10-7 |
| NCAAF | 2022/09/03 16:00 | South Dakota State v Iowa | W | 3-7 |
| NCAAF Bowl Games | 2022/01/01 18:00 | Kentucky v Iowa | L | 20-17 |
| NCAAF | 2021/12/05 01:00 | Iowa v Michigan | L | 3-42 |
Away History
| NCAAF | 2022/10/08 20:00 | Ohio State v Michigan State | W | 49-20 |
| NCAAF | 2022/10/01 19:30 | Rutgers v Ohio State | W | 10-49 |
| NCAAF | 2022/09/24 23:30 | Wisconsin v Ohio State | W | 21-52 |
| NCAAF | 2022/09/17 23:00 | Toledo v Ohio State | W | 21-77 |
| NCAAF | 2022/09/10 16:00 | Arkansas State v Ohio State | W | 12-45 |
| NCAAF | 2022/09/03 23:30 | Notre Dame v Ohio State | W | 10-21 |
| NCAAF Bowl Games | 2022/01/01 22:00 | Utah v Ohio State | W | 45-48 |
| NCAAF | 2021/11/27 17:00 | Ohio State v Michigan | L | 27-42 |