[5] Iowa 10-54 Ohio State [1] 2022-10-22 16:00
Stadium: Ohio Stadium Round: 1
Home Manager: Ryan Day Away Manager: Kirk Ferentz
Head to Head
| NCAAF | 2017/11/04 19:30 | Ohio State v Iowa | W | 24-55 |
| NCAAF | 2010/11/20 12:00 | Iowa v Ohio State | L | 17-20 |
| NCAAF | 2009/11/14 12:00 | Ohio State v Iowa | L | 27-24 |
| NCAAF | 2006/09/30 12:00 | Iowa v Ohio State | L | 17-38 |
| NCAAF | 2005/09/24 12:00 | Ohio State v Iowa | L | 31-6 |
| NCAAF | 2004/10/16 12:00 | Iowa v Ohio State | W | 33-7 |
| NCAAF | 2003/10/18 12:00 | Ohio State v Iowa | L | 19-10 |
| NCAAF | 2000/10/21 12:00 | Iowa v Ohio State | L | 10-38 |