[12] Pittsburgh 10-24 Louisville [14] 2022-10-23 00:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Pat Narduzzi
Head to Head
| NCAAF | 2020/09/26 16:00 | Louisville v Pittsburgh | W | 20-23 |
| NCAAF | 2015/11/21 20:45 | Pittsburgh v Louisville | W | 45-34 |
| NCAAF | 2012/10/13 12:00 | Pittsburgh v Louisville | L | 35-45 |
| NCAAF | 2011/11/12 12:00 | Louisville v Pittsburgh | W | 14-21 |
| NCAAF | 2010/10/30 12:00 | Pittsburgh v Louisville | W | 20-3 |
| NCAAF | 2008/11/08 12:00 | Pittsburgh v Louisville | W | 41-7 |
| NCAAF | 2007/10/27 12:00 | Louisville v Pittsburgh | L | 24-17 |
| NCAAF | 2006/11/25 12:00 | Pittsburgh v Louisville | L | 24-48 |
Home History
| NCAAF | 2022/10/08 19:30 | Virginia Tech v Pittsburgh | W | 29-45 |
| NCAAF | 2022/10/02 00:00 | Georgia Tech v Pittsburgh | L | 26-21 |
| NCAAF | 2022/09/24 16:00 | Rhode Island v Pittsburgh | W | 24-45 |
| NCAAF | 2022/09/17 23:30 | Pittsburgh v Western Michigan | W | 34-13 |
| NCAAF | 2022/09/10 19:30 | Tennessee v Pittsburgh | L | 34-27 |
| NCAAF | 2022/09/01 23:00 | West Virginia v Pittsburgh | W | 31-38 |
| NCAAF Bowl Games | 2021/12/31 00:00 | Pittsburgh v Michigan State | L | 21-31 |
| NCAAF | 2021/12/05 01:00 | Wake Forest v Pittsburgh | W | 21-45 |
Away History
| NCAAF | 2022/10/08 16:00 | Louisville v Virginia | W | 34-17 |
| NCAAF | 2022/10/01 16:00 | Louisville v Boston College | L | 33-34 |
| NCAAF | 2022/09/24 16:00 | South Florida v Louisville | W | 3-41 |
| NCAAF | 2022/09/16 23:30 | Florida State v Louisville | L | 35-31 |
| NCAAF | 2022/09/09 23:30 | Louisville v Central Florida | W | 20-14 |
| NCAAF | 2022/09/04 00:00 | Louisville v Syracuse | L | 7-31 |
| NCAAF Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |