[12] Pittsburgh 10-24 Louisville [14] 2022-10-23 00:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Pat Narduzzi
Head to Head
| NCAAF | 2020/09/26 16:00 | Louisville v Pittsburgh | W | 20-23 |
| NCAAF | 2015/11/21 20:45 | Pittsburgh v Louisville | W | 45-34 |
| NCAAF | 2012/10/13 12:00 | Pittsburgh v Louisville | L | 35-45 |
| NCAAF | 2011/11/12 12:00 | Louisville v Pittsburgh | W | 14-21 |
| NCAAF | 2010/10/30 12:00 | Pittsburgh v Louisville | W | 20-3 |
| NCAAF | 2008/11/08 12:00 | Pittsburgh v Louisville | W | 41-7 |
| NCAAF | 2007/10/27 12:00 | Louisville v Pittsburgh | L | 24-17 |
| NCAAF | 2006/11/25 12:00 | Pittsburgh v Louisville | L | 24-48 |
| NCAAF | 2005/11/03 12:00 | Louisville v Pittsburgh | L | 42-20 |