[6] Missouri 23-10 South Carolina [5] 2022-10-29 20:00
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Shane Beamer Away Manager: Eliah Drinkwitz
Head to Head
| NCAAF | 2021/11/13 21:00 | South Carolina v Missouri | W | 28-31 |
| NCAAF | 2020/11/22 00:30 | Missouri v South Carolina | W | 17-10 |
| NCAAF | 2019/09/21 20:00 | South Carolina v Missouri | W | 14-34 |
| NCAAF | 2018/10/06 16:00 | Missouri v South Carolina | L | 35-37 |
| NCAAF | 2017/09/09 23:00 | South Carolina v Missouri | L | 31-13 |
| NCAAF | 2016/11/05 20:00 | Missouri v South Carolina | L | 21-31 |
| NCAAF | 2015/10/03 16:00 | Missouri v South Carolina | W | 24-10 |
| NCAAF | 2014/09/27 23:00 | South Carolina v Missouri | W | 20-21 |
Home History
| NCAAF | 2022/10/22 20:00 | Vanderbilt v Missouri | W | 14-17 |
| NCAAF | 2022/10/08 16:00 | Missouri v Florida | L | 17-24 |
| NCAAF | 2022/10/01 23:30 | Georgia v Missouri | L | 26-22 |
| NCAAF | 2022/09/24 16:00 | Missouri v Auburn | L | 14-17 |
| NCAAF | 2022/09/17 16:00 | Abilene Christian v Missouri | W | 17-34 |
| NCAAF | 2022/09/10 16:00 | Missouri v Kansas State | L | 12-40 |
| NCAAF | 2022/09/02 00:00 | Louisiana Tech v Missouri | W | 24-52 |
| NCAAF Bowl Games | 2021/12/23 01:00 | Missouri v Army | L | 22-24 |
Away History
| NCAAF | 2022/10/22 23:30 | Texas A&M v South Carolina | W | 24-30 |
| NCAAF | 2022/10/08 23:30 | South Carolina v Kentucky | W | 24-14 |
| NCAAF | 2022/09/29 23:00 | South Carolina State v South Carolina | W | 10-50 |
| NCAAF | 2022/09/24 23:30 | Charlotte v South Carolina | W | 20-56 |
| NCAAF | 2022/09/17 16:00 | Georgia v South Carolina | L | 48-7 |
| NCAAF | 2022/09/10 16:00 | South Carolina v Arkansas | L | 30-44 |
| NCAAF | 2022/09/03 23:30 | Georgia State v South Carolina | W | 14-35 |
| NCAAF Bowl Games | 2021/12/30 16:30 | South Carolina v North Carolina | W | 38-21 |