[6] Missouri 23-10 South Carolina [5] 2022-10-29 20:00
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Shane Beamer Away Manager: Eliah Drinkwitz
Head to Head
| NCAAF | 2021/11/13 21:00 | South Carolina v Missouri | W | 28-31 |
| NCAAF | 2020/11/22 00:30 | Missouri v South Carolina | W | 17-10 |
| NCAAF | 2019/09/21 20:00 | South Carolina v Missouri | W | 14-34 |
| NCAAF | 2018/10/06 16:00 | Missouri v South Carolina | L | 35-37 |
| NCAAF | 2017/09/09 23:00 | South Carolina v Missouri | L | 31-13 |
| NCAAF | 2016/11/05 20:00 | Missouri v South Carolina | L | 21-31 |
| NCAAF | 2015/10/03 16:00 | Missouri v South Carolina | W | 24-10 |
| NCAAF | 2014/09/27 23:00 | South Carolina v Missouri | W | 20-21 |
| NCAAF | 2012/09/22 12:00 | South Carolina v Missouri | L | 31-10 |
| NCAAF Bowl Games | 2005/12/30 12:00 | Missouri v South Carolina | W | 38-31 |