Illinois 15-23 Michigan State 2022-11-05 19:30
Stadium: Memorial Stadium (Champaign, IL) Round: 1
Home Manager: Bret Bielema Away Manager: Melvin Tucker
Head to Head
| NCAAF | 2019/11/09 20:30 | Illinois v Michigan State | W | 37-34 |
| NCAAF | 2016/11/05 16:00 | Michigan State v Illinois | W | 27-31 |
| NCAAF | 2010/10/16 12:00 | Michigan State v Illinois | L | 26-6 |
| NCAAF | 2009/10/10 12:00 | Illinois v Michigan State | L | 14-24 |
| NCAAF | 2006/09/30 12:00 | Michigan State v Illinois | W | 20-23 |
| NCAAF | 2005/09/24 12:00 | Illinois v Michigan State | L | 14-61 |
| NCAAF | 2004/10/09 12:00 | Michigan State v Illinois | L | 38-25 |
| NCAAF | 2003/10/11 12:00 | Illinois v Michigan State | L | 14-49 |
Home History
| NCAAF | 2022/10/29 19:30 | Illinois v Nebraska | W | 26-9 |
| NCAAF | 2022/10/15 16:00 | Minnesota v Illinois | W | 14-26 |
| NCAAF | 2022/10/08 23:30 | Iowa v Illinois | W | 6-9 |
| NCAAF | 2022/10/01 16:00 | Illinois v Wisconsin | W | 34-10 |
| NCAAF | 2022/09/23 00:30 | Tennessee Chattanooga v Illinois | W | 0-31 |
| NCAAF | 2022/09/10 20:00 | Virginia v Illinois | W | 3-24 |
| NCAAF | 2022/09/03 00:00 | Illinois v Indiana | L | 20-23 |
| NCAAF | 2022/08/27 20:00 | Wyoming v Illinois | W | 6-38 |
Away History
| NCAAF | 2022/10/29 23:30 | Michigan State v Michigan | L | 7-29 |
| NCAAF | 2022/10/15 20:00 | Wisconsin v Michigan State | W | 28-34 |
| NCAAF | 2022/10/08 20:00 | Ohio State v Michigan State | L | 49-20 |
| NCAAF | 2022/10/01 19:30 | Michigan State v Maryland | L | 13-27 |
| NCAAF | 2022/09/24 19:30 | Minnesota v Michigan State | L | 34-7 |
| NCAAF | 2022/09/17 23:30 | Michigan State v Washington | L | 28-39 |
| NCAAF | 2022/09/10 20:00 | Akron v Michigan State | W | 0-52 |
| NCAAF | 2022/09/02 23:00 | Western Michigan v Michigan State | W | 13-35 |