Illinois 15-23 Michigan State 2022-11-05 19:30
Stadium: Memorial Stadium (Champaign, IL) Round: 1
Home Manager: Bret Bielema Away Manager: Melvin Tucker
Head to Head
| NCAAF | 2019/11/09 20:30 | Illinois v Michigan State | W | 37-34 |
| NCAAF | 2016/11/05 16:00 | Michigan State v Illinois | W | 27-31 |
| NCAAF | 2010/10/16 12:00 | Michigan State v Illinois | L | 26-6 |
| NCAAF | 2009/10/10 12:00 | Illinois v Michigan State | L | 14-24 |
| NCAAF | 2006/09/30 12:00 | Michigan State v Illinois | W | 20-23 |
| NCAAF | 2005/09/24 12:00 | Illinois v Michigan State | L | 14-61 |
| NCAAF | 2004/10/09 12:00 | Michigan State v Illinois | L | 38-25 |
| NCAAF | 2003/10/11 12:00 | Illinois v Michigan State | L | 14-49 |
| NCAAF | 2000/10/28 12:00 | Michigan State v Illinois | L | 14-10 |