[14] Universitario de Sucre 3-1 Real Santa Cruz [13] 2022-09-07 22:00
Stadium: Estadio Olimpico Patria Round: 16
Head to Head
| Bolivia Clausura | 2022/07/01 19:00 | Real Santa Cruz v Universitario de Sucre | L | 3-0 |
| Bolivia Apertura | 2022/04/16 00:00 | Universitario de Sucre v Real Santa Cruz | L | 2-3 |
| Bolivia Apertura | 2022/02/06 16:00 | Real Santa Cruz v Universitario de Sucre | W | 0-1 |
Home History
| Bolivia Clausura | 2022/09/04 00:15 | Real Tomayapo v Universitario de Sucre | D | 1-1 |
| Bolivia Clausura | 2022/08/31 00:15 | Universitario de Sucre v Bolivar | L | 2-3 |
| Bolivia Clausura | 2022/08/28 00:15 | Blooming v Universitario de Sucre | D | 1-1 |
| Bolivia Clausura | 2022/08/24 22:00 | Universitario de Sucre v Atletico Palmaflor Vinto | W | 2-1 |
| Bolivia Clausura | 2022/08/20 23:30 | Jorge Wilstermann v Universitario de Sucre | L | 5-1 |
| Bolivia Clausura | 2022/08/14 21:00 | Universitario de Sucre v Universitario De Vinto | W | 2-1 |
| Bolivia Clausura | 2022/08/12 00:15 | Universitario de Sucre v Nacional Potosi | L | 0-1 |
| Bolivia Clausura | 2022/08/07 23:30 | Club Aurora v Universitario de Sucre | D | 1-1 |
Away History
| Bolivia Clausura | 2022/09/04 19:00 | Guabira v Real Santa Cruz | L | 2-1 |
| Bolivia Clausura | 2022/09/01 19:00 | Real Santa Cruz v Jorge Wilstermann | D | 0-0 |
| Bolivia Clausura | 2022/08/26 19:00 | Universitario De Vinto v Real Santa Cruz | L | 2-0 |
| Bolivia Clausura | 2022/08/23 19:00 | Real Santa Cruz v Royal Pari FC | W | 2-1 |
| Bolivia Clausura | 2022/08/20 00:15 | Independiente Petrolero v Real Santa Cruz | L | 1-0 |
| Bolivia Clausura | 2022/08/13 19:00 | Real Santa Cruz v Bolivar | L | 1-2 |
| Bolivia Clausura | 2022/08/10 19:00 | Real Santa Cruz v The Strongest | L | 0-3 |
| Bolivia Clausura | 2022/08/05 19:00 | Always Ready v Real Santa Cruz | L | 4-0 |