[14] Universitario de Sucre 3-1 Real Santa Cruz [13] 2022-09-07 22:00
Stadium: Estadio Olimpico Patria Round: 16
Head to Head
| Bolivia Clausura | 2022/07/01 19:00 | Real Santa Cruz v Universitario de Sucre | L | 3-0 |
| Bolivia Apertura | 2022/04/16 00:00 | Universitario de Sucre v Real Santa Cruz | L | 2-3 |
| Bolivia Apertura | 2022/02/06 16:00 | Real Santa Cruz v Universitario de Sucre | W | 0-1 |