[13] St Lucia 0-4 Birkirkara [4] 2022-09-11 18:45
Stadium: Luxol Sports Ground Round: 4
Home Manager: Pablo Cortes Away Manager: Jonathan Holland
Head to Head
| Malta Premier League | 2022/02/27 13:00 | Birkirkara v Santa Lucia FC | W | 2-3 |
| Malta Premier League | 2021/11/21 10:30 | Santa Lucia FC v Birkirkara | W | 2-0 |
| Malta Premier League | 2021/01/10 13:00 | Santa Lucia FC v Birkirkara | D | 0-0 |
| Malta Premier League | 2019/11/09 15:15 | Santa Lucia FC v Birkirkara | L | 0-2 |
| Europe Friendlies | 2018/07/26 16:09 | Birkirkara v Santa Lucia FC | L | 1-0 |
| Malta FA Trophy | 2017/12/02 13:00 | Santa Lucia FC v Birkirkara | L | 0-5 |
Home History
| Malta Premier League | 2022/09/03 16:30 | Zebbug Rangers FC v Santa Lucia FC | L | 2-0 |
| Malta Premier League | 2022/08/28 16:30 | Santa Lucia FC v Balzan FC | L | 0-2 |
| Malta Premier League | 2022/08/20 16:30 | Gzira United v Santa Lucia FC | L | 3-1 |
| Malta FA Trophy | 2022/05/10 17:30 | Santa Lucia FC v Valletta | L | 0-1 |
| Malta Premier League | 2022/05/06 17:00 | Valletta v Santa Lucia FC | L | 2-1 |
| Malta Premier League | 2022/05/01 14:00 | Santa Lucia FC v Sliema Wanderers | L | 1-2 |
| Malta Premier League | 2022/04/24 14:00 | Mosta FC v Santa Lucia FC | D | 1-1 |
| Malta FA Trophy | 2022/04/18 17:00 | Gzira United v Santa Lucia FC | D | 0-0 |
Away History
| Malta Premier League | 2022/09/03 16:30 | Birkirkara v Floriana | W | 1-0 |
| Malta Premier League | 2022/08/27 16:30 | Zebbug Rangers FC v Birkirkara | W | 1-2 |
| Malta Premier League | 2022/08/19 16:30 | Birkirkara v Sirens | W | 2-0 |
| Europe Friendlies | 2022/08/06 16:29 | Birkirkara v Balzan FC | L | 0-3 |
| Europe Friendlies | 2022/07/26 18:00 | Marsaxlokk FC v Birkirkara | D | 1-1 |
| Europe Friendlies | 2022/07/16 18:15 | Birkirkara v Pieta Hotspurs | L | 1-2 |
| Malta Premier League | 2022/05/07 14:00 | Birkirkara v Hamrun Spartans | L | 0-1 |
| Malta Premier League | 2022/05/01 13:00 | Hibernians v Birkirkara | L | 3-1 |