Head to Head
| Mexico Liga MX | 2023/02/05 03:05 | Santos Laguna v Club America | D | 2-2 |
| Mexico Liga MX | 2022/09/15 02:05 | Club America v Santos Laguna | D | 3-3 |
| Mexico Liga MX | 2022/02/13 03:00 | Santos Laguna v Club America | W | 2-3 |
| Mexico Liga MX | 2021/10/20 00:05 | Club America v Santos Laguna | W | 2-1 |
| Club Friendly List | 2021/07/05 00:30 | Club America v Santos Laguna | W | 1-0 |
| Mexico Liga MX | 2021/02/01 01:06 | Santos Laguna v Club America | D | 1-1 |
| Mexico Liga MX | 2020/08/14 02:00 | Club America v Santos Laguna | W | 3-1 |
| Mexico Liga MX | 2019/11/03 01:00 | Club America v Santos Laguna | L | 1-2 |
Home History
| Mexico Liga MX | 2023/03/19 03:10 | Chivas Guadalajara v Club America | W | 2-4 |
| Mexico Liga MX | 2023/03/12 03:10 | Tigres UANL v Club America | W | 0-2 |
| Mexico Liga MX | 2023/03/05 01:05 | Club America v Pachuca | L | 0-3 |
| Mexico Liga MX | 2023/02/26 03:05 | Atlas v Club America | D | 2-2 |
| Mexico Liga MX | 2023/02/20 01:05 | Club America v Tijuana | W | 2-1 |
| Mexico Liga MX | 2023/02/15 03:05 | Atletico San Luis v Club America | W | 1-3 |
| Mexico Liga MX | 2023/02/11 23:00 | Club America v Necaxa | W | 2-1 |
| Mexico Liga MX | 2023/02/05 03:05 | Santos Laguna v Club America | D | 2-2 |
Away History
| Mexico Liga MX | 2023/03/20 03:05 | Leon v Santos Laguna | L | 4-1 |
| Mexico Liga MX | 2023/03/13 01:05 | Santos Laguna v Tijuana | W | 3-2 |
| Mexico Liga MX | 2023/03/05 03:05 | Chivas Guadalajara v Santos Laguna | L | 2-0 |
| Mexico Liga MX | 2023/02/27 01:05 | Santos Laguna v Puebla | W | 3-2 |
| Mexico Liga MX | 2023/02/24 02:00 | Santos Laguna v Toluca | L | 0-5 |
| Mexico Liga MX | 2023/02/18 23:00 | Atletico San Luis v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2023/02/12 01:05 | Juarez FC v Santos Laguna | L | 3-1 |
| Mexico Liga MX | 2023/02/05 03:05 | Santos Laguna v Club America | D | 2-2 |