Head to Head
| NFL Preseason | 2022/08/13 20:00 | IND Colts v BUF Bills | L | 24-27 |
| NFL | 2021/11/21 18:00 | IND Colts v BUF Bills | W | 41-15 |
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | L | 24-27 |
| NFL Preseason | 2019/08/08 23:00 | IND Colts v BUF Bills | L | 16-24 |
| NFL | 2018/10/21 17:00 | BUF Bills v IND Colts | W | 5-37 |
| NFL | 2017/12/10 18:00 | IND Colts v BUF Bills | L | 7-13 |
| NFL Preseason | 2016/08/13 23:00 | BUF Bills v IND Colts | W | 18-19 |
| NFL | 2015/09/13 17:00 | BUF Bills v IND Colts | L | 27-14 |
Home History
| NFL | 2023/01/08 18:00 | HOU Texans v IND Colts | L | 32-31 |
| NFL | 2023/01/01 18:00 | IND Colts v NY Giants | L | 10-38 |
| NFL | 2022/12/27 01:15 | LA Chargers v IND Colts | L | 20-3 |
| NFL | 2022/12/17 18:00 | IND Colts v MIN Vikings | L | 36-39 |
| NFL | 2022/12/05 01:20 | IND Colts v DAL Cowboys | L | 19-54 |
| NFL | 2022/11/29 01:15 | PIT Steelers v IND Colts | L | 24-17 |
| NFL | 2022/11/20 18:00 | PHI Eagles v IND Colts | L | 17-16 |
| NFL | 2022/11/13 21:05 | IND Colts v LV Raiders | W | 25-20 |
Away History
| NFL | 2023/01/22 20:00 | CIN Bengals v BUF Bills | L | 27-10 |
| NFL | 2023/01/15 18:05 | MIA Dolphins v BUF Bills | W | 31-34 |
| NFL | 2023/01/08 18:00 | NE Patriots v BUF Bills | W | 23-35 |
| NFL | 2022/12/24 18:00 | BUF Bills v CHI Bears | W | 35-13 |
| NFL | 2022/12/18 01:15 | MIA Dolphins v BUF Bills | W | 29-32 |
| NFL | 2022/12/11 18:00 | NY Jets v BUF Bills | W | 12-20 |
| NFL | 2022/12/02 01:15 | BUF Bills v NE Patriots | W | 24-10 |
| NFL | 2022/11/24 17:30 | BUF Bills v DET Lions | W | 28-25 |