Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2022/10/29 18:00 | Missouri Western Griffons v Missouri Southern Lions | L | 31-27 |
| NCAAF | 2021/10/30 19:00 | Missouri Southern Lions v Missouri Western Griffons | L | 28-45 |
| NCAAF | 2019/10/12 21:00 | Missouri Western Griffons v Missouri Southern Lions | L | 43-34 |
| NCAAF | 2018/10/06 19:00 | Missouri Southern Lions v Missouri Western Griffons | L | 10-33 |
| NCAAF | 2023/11/04 18:00 | Emporia State v Missouri Southern Lions | L | 63-28 |
| NCAAF | 2023/10/28 19:00 | Missouri Southern Lions v Central Missouri Mules | L | 21-42 |
| NCAAF | 2023/10/21 19:00 | Blue Tigers v Missouri Southern Lions | W | 5-63 |
| NCAAF | 2023/10/14 19:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 21-31 |
| NCAAF | 2023/10/07 19:00 | Missouri Southern Lions v Fort Hays State University Tigers | L | 22-35 |
| NCAAF | 2023/09/30 19:00 | Central Oklahoma v Missouri Southern Lions | L | 30-27 |
| NCAAF | 2023/09/23 19:00 | Missouri Southern Lions v Northeastern State Riverhawks | W | 42-0 |
| NCAAF | 2023/09/16 17:00 | Nebraska Kearney v Missouri Southern Lions | W | 13-18 |
| NCAAF | 2023/11/04 18:00 | Missouri Western Griffons v Pittsburgh State Gorillas | W | 31-30 |
| NCAAF | 2023/10/28 18:00 | Missouri Western Griffons v Northeastern State Riverhawks | W | 44-0 |
| NCAAF | 2023/10/21 17:00 | Nebraska Kearney v Missouri Western Griffons | W | 17-20 |
| NCAAF | 2023/10/14 18:00 | Missouri Western Griffons v NW Missouri State | L | 23-27 |
| NCAAF | 2023/10/07 20:00 | Washburn Ichabods Football v Missouri Western Griffons | W | 21-61 |
| NCAAF | 2023/09/30 21:00 | Missouri Western Griffons v Emporia State | W | 34-31 |
| NCAAF | 2023/09/23 18:00 | Missouri Western Griffons v Fort Hays State University Tigers | W | 28-7 |
| NCAAF | 2023/09/16 19:00 | Central Oklahoma v Missouri Western Griffons | W | 31-34 |