Stadium: Armfield Athletic Center Round: 1
| NCAAF | 2022/10/29 17:00 | Hampden Sydney Tigers v Guilford Quakers | L | 28-21 |
| NCAAF | 2021/09/25 17:00 | Guilford Quakers v Hampden Sydney Tigers | L | 27-28 |
| NCAAF | 2019/10/26 17:00 | Guilford Quakers v Hampden Sydney Tigers | W | 37-27 |
| NCAAF | 2018/10/20 17:00 | Hampden Sydney Tigers v Guilford Quakers | L | 38-35 |
| NCAAF | 2023/10/21 19:30 | Ferrum Panthers v Guilford Quakers | L | 28-0 |
| NCAAF | 2023/10/14 17:00 | Guilford Quakers v Shenandoah Hornets | L | 20-31 |
| NCAAF | 2023/10/07 20:00 | Washington And Lee Generals v Guilford Quakers | L | 48-25 |
| NCAAF | 2023/09/30 17:00 | Guilford Quakers v Randolph Macon Yellow Jackets | L | 14-70 |
| NCAAF | 2023/09/16 18:00 | Huntingdon Hawks v Guilford Quakers | L | 40-14 |
| NCAAF | 2023/09/09 22:00 | Methodist Monarchs v Guilford Quakers | W | 21-39 |
| NCAAF | 2023/09/02 23:00 | Guilford Quakers v Greensboro Pride | W | 36-21 |
| NCAAF | 2022/11/12 18:00 | Guilford Quakers v Bridgewater Eagles | L | 22-64 |
| NCAAF | 2023/10/21 17:00 | Hampden Sydney Tigers v Washington And Lee Generals | L | 17-21 |
| NCAAF | 2023/10/14 20:00 | Averett Cougars v Hampden Sydney Tigers | W | 28-31 |
| NCAAF | 2023/10/07 17:00 | Hampden Sydney Tigers v Ferrum Panthers | W | 48-10 |
| NCAAF | 2023/09/30 17:00 | Hampden Sydney Tigers v Bridgewater Eagles | L | 38-39 |
| NCAAF | 2023/09/16 16:00 | Greensboro Pride v Hampden Sydney Tigers | W | 28-58 |
| NCAAF | 2023/09/09 17:00 | Hampden Sydney Tigers v Brevard Tornados | W | 31-17 |
| NCAAF | 2023/09/02 17:00 | Hampden Sydney Tigers v Wabash Little Giants | L | 28-29 |
| NCAAF | 2022/11/12 18:00 | Hampden Sydney Tigers v Randolph Macon Yellow Jackets | L | 17-38 |