Stadium: Armfield Athletic Center Round: 1
| NCAAF | 2022/10/29 17:00 | Hampden Sydney Tigers v Guilford Quakers | L | 28-21 |
| NCAAF | 2021/09/25 17:00 | Guilford Quakers v Hampden Sydney Tigers | L | 27-28 |
| NCAAF | 2019/10/26 17:00 | Guilford Quakers v Hampden Sydney Tigers | W | 37-27 |
| NCAAF | 2018/10/20 17:00 | Hampden Sydney Tigers v Guilford Quakers | L | 38-35 |