[4] Santos Laguna 1-1 Club America [2] 2018-11-12 00:00
Stadium: Estadio TSM Corona Round: 16
Referee: Jorge Isaac Rojas Castillo Home Manager: Salvador Reyes Away Manager: Miguel Herrera
Head to Head
| Mexico Liga MX | 2018/05/14 00:00 | Club America v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2018/05/11 00:30 | Santos Laguna v Club America | W | 4-1 |
| Mexico Liga MX | 2018/04/29 02:00 | Club America v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2017/11/20 00:30 | Santos Laguna v Club America | L | 0-1 |
| Club Friendly List | 2017/07/06 01:30 | Club America v Santos Laguna | L | 3-2 |
| Mexico Liga MX | 2017/04/24 00:00 | Santos Laguna v Club America | W | 2-1 |
| Mexico Cup | 2017/03/02 02:30 | Santos Laguna v Club America | W | 2-1 |
| Mexico Cup | 2017/01/19 02:30 | Club America v Santos Laguna | L | 3-2 |
Home History
| Mexico Liga MX | 2018/11/04 22:00 | Queretaro v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2018/10/27 00:00 | Santos Laguna v Monterrey | W | 1-0 |
| Mexico Liga MX | 2018/10/21 00:00 | Pachuca v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2018/10/06 00:00 | Santos Laguna v Atlas | W | 3-1 |
| Mexico Liga MX | 2018/09/30 02:00 | Necaxa v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2018/09/23 23:00 | Santos Laguna v Veracruz | D | 1-1 |
| Mexico Liga MX | 2018/09/16 21:00 | Santos Laguna v Leon | W | 3-0 |
| World Club Friendlies | 2018/09/05 23:41 | Charlotte Independence v Santos Laguna | W | 0-3 |
Away History
| Mexico Liga MX | 2018/11/04 01:00 | Club America v Toluca | D | 1-1 |
| Mexico Liga MX | 2018/10/28 02:00 | Cruz Azul v Club America | D | 0-0 |
| Mexico Liga MX | 2018/10/21 00:00 | Club America v Tijuana | W | 3-0 |
| Mexico Liga MX | 2018/10/07 00:00 | Tigres UANL v Club America | W | 2-3 |
| Mexico Liga MX | 2018/09/30 23:00 | Club America v Chivas Guadalajara | D | 1-1 |
| Mexico Cup | 2018/09/26 02:15 | Club America v Juarez FC | L | 10-11 |
| Mexico Liga MX | 2018/09/22 02:00 | Puebla v Club America | W | 2-3 |
| Mexico Liga MX | 2018/09/16 00:00 | Club America v Atletico Morelia | W | 2-1 |