[3] Juan M Del Potro 6-7,6-3,7-6,6-2 John Isner [11] 2018-09-04 17:45
Stadium: Arthur Ashe Stadium Round: 27 Ground: Hardcourt outdoor
Head to Head
| French Open | 2018/06/04 14:40 | John Isner v Juan Martin Del Potro | 4-6,4-6,4-6 |
| ATP Miami | 2018/03/30 17:00 | Juan Martin Del Potro v John Isner | 1-6,6-7 |
| ATP Paris | 2017/11/03 13:00 | Juan Martin Del Potro v John Isner | 4-6,7-6,4-6 |
| ATP Montreal | 2017/08/07 22:30 | Juan Martin Del Potro v John Isner | 7-5,7-5 |
| ATP Stockholm | 2016/10/19 16:30 | John Isner v Juan Martin Del Potro | 4-6,6-7 |
Home History
| US Open | 2018/09/03 00:50 | Juan Martin Del Potro v Borna Coric | 6-4,6-3,6-1 |
| US Open | 2018/09/01 01:25 | Juan Martin Del Potro v Fernando Verdasco | 7-5,7-6,6-3 |
| US Open | 2018/08/29 19:20 | Juan Martin Del Potro v Denis Kudla | 6-3,6-1,7-6 |
| US Open | 2018/08/28 00:50 | Juan Martin Del Potro v Donald Young | 6-0,6-3,6-4 |
| ATP Cincinnati | 2018/08/17 23:50 | David Goffin v Juan Martin Del Potro | 7-6,7-6 |
| ATP Cincinnati | 2018/08/17 15:00 | Nick Kyrgios v Juan Martin Del Potro | 6-7,7-6,2-6 |
| ATP Cincinnati | 2018/08/16 19:00 | Hyeon Chung v Juan Martin Del Potro | 2-6,3-6 |
| ATP Los Cabos | 2018/08/05 03:00 | Juan Martin Del Potro v Fabio Fognini | 4-6,2-6 |
Away History
| US Open | 2018/09/02 19:45 | John Isner v Milos Raonic | 3-6,6-3,6-4,3-6,6-2 |
| US Open | 2018/08/31 21:00 | John Isner v Dusan Lajovic | 7-6,6-7,6-3,7-5 |
| US Open | 2018/08/29 20:45 | John Isner v Nicolas Jarry | 6-7,6-4,3-6,7-6,6-4 |
| US Open | 2018/08/27 16:50 | John Isner v Bradley Klahn | 7-6,6-3,6-4 |
| ATP Cincinnati | 2018/08/13 20:15 | John Isner v Sam Querrey | 4-6,7-6,6-7 |
| ATP Toronto | 2018/08/09 22:40 | Karen Khachanov v John Isner | 7-6,7-6 |
| ATP Toronto | 2018/08/08 20:00 | Pierre-Hugues Herbert v John Isner | 6-7,2-6 |
| ATP Washington | 2018/08/02 21:30 | Noah Rubin v John Isner | 6-4,7-6 |