Stadium: O'Brien Stadium Round: 1
Home Manager: Kim Dameron Away Manager: Curt Mallory
| NCAAF | 2018/09/08 23:00 | Indiana State v Louisville | L | 7-31 |
| NCAAF | 2018/08/30 23:00 | Indiana State v Quincy | W | 49-0 |
| NCAAF | 2017/11/18 22:00 | Northern Iowa v Indiana State | L | 41-3 |
| NCAAF | 2017/11/11 18:00 | Indiana State v Western Illinois | L | 0-45 |
| NCAAF | 2017/11/04 17:00 | Indiana State v Youngstown State | L | 24-66 |
| NCAAF | 2017/10/28 19:00 | Missouri St v Indiana State | L | 59-20 |
| NCAAF | 2017/10/21 19:00 | Indiana State v SO Illinois | L | 24-45 |
| NCAAF | 2017/10/14 19:00 | South Dakota v Indiana State | L | 56-6 |
| NCAAF | 2018/09/08 23:30 | Eastern Illinois v Illinois State | L | 10-48 |
| NCAAF | 2018/09/01 20:00 | Eastern Illinois v Arkansas | L | 20-55 |
| NCAAF | 2017/11/18 23:00 | Austin Peay v Eastern Illinois | L | 28-13 |
| NCAAF | 2017/11/04 18:00 | Eastern Illinois v Eastern Kentucky | W | 23-20 |
| NCAAF | 2017/10/28 19:00 | Tennessee Martin v Eastern Illinois | L | 27-10 |
| NCAAF | 2017/10/21 19:00 | Eastern Illinois v Jacksonville State | L | 14-30 |
| NCAAF | 2017/10/14 20:00 | Murray State v Eastern Illinois | W | 24-27 |
| NCAAF | 2017/10/07 23:00 | Eastern Illinois v Tennessee Tech | W | 24-23 |