Stadium: Hancock Stadium Round: 1
Home Manager: Brock Spack Away Manager: Kim Dameron
| NCAAF | 2018/09/01 20:00 | Eastern Illinois v Arkansas | L | 20-55 |
| NCAAF | 2017/11/18 23:00 | Austin Peay v Eastern Illinois | L | 28-13 |
| NCAAF | 2017/11/04 18:00 | Eastern Illinois v Eastern Kentucky | W | 23-20 |
| NCAAF | 2017/10/28 19:00 | Tennessee Martin v Eastern Illinois | L | 27-10 |
| NCAAF | 2017/10/21 19:00 | Eastern Illinois v Jacksonville State | L | 14-30 |
| NCAAF | 2017/10/14 20:00 | Murray State v Eastern Illinois | W | 24-27 |
| NCAAF | 2017/10/07 23:00 | Eastern Illinois v Tennessee Tech | W | 24-23 |
| NCAAF | 2017/09/30 23:00 | Tennessee State v Eastern Illinois | W | 16-19 |
| NCAAF | 2018/09/01 23:30 | Illinois State v Saint Xavier Cougars | W | 46-0 |
| NCAAF | 2017/11/18 18:00 | Illinois State v North Dakota State | L | 7-20 |
| NCAAF | 2017/11/11 20:00 | South Dakota State v Illinois State | L | 27-24 |
| NCAAF | 2017/11/04 17:00 | Illinois State v Western Illinois | L | 14-31 |
| NCAAF | 2017/10/28 18:00 | Youngstown State v Illinois State | W | 0-35 |
| NCAAF | 2017/10/21 19:00 | Illinois State v South Dakota | W | 37-21 |
| NCAAF | 2017/10/14 19:00 | SO Illinois v Illinois State | L | 42-7 |
| NCAAF | 2017/10/07 23:00 | Northern Arizona v Illinois State | L | 37-16 |