Stadium: Dana J. Dykhouse Stadium Round: 1
Home Manager: John Stiegelmeier Away Manager: Dave Steckel
| NCAAF | 2018/10/27 19:00 | Missouri St v SO Illinois | L | 35-49 |
| NCAAF | 2018/10/20 19:00 | Missouri St v Western Illinois | L | 14-31 |
| NCAAF | 2018/10/13 18:00 | Missouri St v Indiana State | W | 29-26 |
| NCAAF | 2018/10/06 19:00 | Missouri St v South Dakota | L | 28-35 |
| NCAAF | 2018/09/29 19:00 | Illinois State v Missouri St | W | 21-24 |
| NCAAF | 2018/09/15 19:00 | Northern Arizona v Missouri St | W | 8-40 |
| NCAAF | 2018/09/06 16:00 | Missouri St v Blue Tigers | W | 52-24 |
| NCAAF | 2018/08/31 00:00 | Missouri St v Oklahoma State | L | 17-58 |
| NCAAF | 2018/10/27 17:00 | Illinois State v South Dakota State | W | 28-38 |
| NCAAF | 2018/10/20 21:00 | Northern Iowa v South Dakota State | L | 24-9 |
| NCAAF | 2018/10/13 19:00 | Youngstown State v South Dakota State | W | 7-36 |
| NCAAF | 2018/10/06 23:00 | Indiana State v South Dakota State | W | 51-54 |
| NCAAF | 2018/09/29 19:30 | South Dakota State v North Dakota State | L | 17-21 |
| NCAAF | 2018/09/15 23:00 | South Dakota State v Arkansas Pine Bluff | W | 90-6 |
| NCAAF | 2018/09/08 23:00 | Montana State v South Dakota State | W | 14-45 |
| NCAAF | 2017/12/16 21:30 | South Dakota State v James Madison | L | 16-51 |