[50] Kansas State 0-45 Iowa State [25] 2020-11-21 21:00
Stadium: Jack Trice Stadium Round: 1
Head to Head
| NCAAF | 2019/12/01 00:00 | Iowa State v Kansas State | W | 17-27 |
| NCAAF | 2018/11/25 00:00 | Kansas State v Iowa State | L | 38-42 |
| NCAAF | 2017/11/25 20:30 | Iowa State v Kansas State | W | 19-20 |
| NCAAF | 2016/10/29 16:00 | Kansas State v Iowa State | W | 31-26 |
| NCAAF | 2015/11/21 17:00 | Kansas State v Iowa State | W | 38-35 |
| NCAAF | 2014/09/06 16:00 | Iowa State v Kansas State | W | 28-32 |
| NCAAF | 2012/10/13 12:00 | Iowa State v Kansas State | W | 21-27 |
| NCAAF | 2011/12/03 12:00 | Kansas State v Iowa State | W | 30-23 |
| NCAAF | 2010/09/18 12:00 | Kansas State v Iowa State | W | 27-20 |
| NCAAF | 2009/10/03 19:00 | Kansas State v Iowa State | W | 24-23 |
| NCAAF | 2008/11/22 12:00 | Kansas State v Iowa State | W | 38-30 |
| NCAAF | 2007/11/03 12:00 | Iowa State v Kansas State | L | 31-20 |
| NCAAF | 2005/11/05 12:00 | Iowa State v Kansas State | L | 45-17 |
| NCAAF | 2004/11/20 12:00 | Kansas State v Iowa State | L | 23-37 |
| NCAAF | 2003/11/08 12:00 | Iowa State v Kansas State | W | 0-45 |
| NCAAF | 2002/11/09 12:00 | Kansas State v Iowa State | W | 58-7 |
| NCAAF | 2001/11/03 12:00 | Iowa State v Kansas State | W | 3-42 |
| NCAAF | 2000/11/04 12:00 | Kansas State v Iowa State | W | 56-10 |