[117] Michigan State 27-24 Michigan [64] 2020-10-31 16:00
Stadium: Michigan Stadium Round: 1
Head to Head
| NCAAF | 2019/11/16 17:00 | Michigan State v Michigan | L | 10-44 |
| NCAAF | 2018/10/20 16:00 | Michigan v Michigan State | L | 21-7 |
| NCAAF | 2017/10/07 23:30 | Michigan State v Michigan | W | 14-10 |
| NCAAF | 2016/10/29 16:00 | Michigan v Michigan State | L | 32-23 |
| NCAAF | 2015/10/17 19:30 | Michigan v Michigan State | W | 23-27 |
| NCAAF | 2014/10/25 19:30 | Michigan State v Michigan | W | 35-11 |
| NCAAF | 2012/10/20 12:00 | Michigan v Michigan State | L | 12-10 |
| NCAAF | 2011/10/15 12:00 | Michigan State v Michigan | W | 28-14 |
| NCAAF | 2010/10/09 12:00 | Michigan v Michigan State | W | 17-34 |
| NCAAF | 2008/10/25 12:00 | Michigan v Michigan State | W | 21-35 |
| NCAAF | 2007/11/03 12:00 | Michigan State v Michigan | L | 24-28 |
| NCAAF | 2006/10/07 12:00 | Michigan v Michigan State | L | 31-13 |
| NCAAF | 2005/10/01 12:00 | Michigan State v Michigan | L | 31-34 |
| NCAAF | 2004/10/30 12:00 | Michigan v Michigan State | L | 45-37 |
| NCAAF | 2003/11/01 12:00 | Michigan State v Michigan | L | 20-27 |
| NCAAF | 2002/11/02 12:00 | Michigan v Michigan State | L | 49-3 |
| NCAAF | 2001/11/03 12:00 | Michigan State v Michigan | W | 26-24 |
| NCAAF | 2000/10/21 12:00 | Michigan v Michigan State | L | 14-0 |