[8] Club America 2-1 Atletico San Luis [7] 2021-01-10 03:00
Stadium: Estadio Azteca Round: 1
Referee: Alejandro Funk Villafane Home Manager: Santiago Hernan Solari Poggio Away Manager: Leonel Rocco
Head to Head
| Mexico Liga MX | 2020/08/30 00:00 | Atletico San Luis v Club America | W | 1-2 |
| Mexico Liga MX | 2019/10/30 01:00 | Atletico San Luis v Club America | W | 0-1 |
| Mexico Cup | 2019/01/31 03:00 | Atletico San Luis v Club America | L | 2-0 |
| Mexico Cup | 2019/01/24 03:00 | Club America v Atletico San Luis | W | 1-0 |