[8] Club America 2-1 Atletico San Luis [7] 2021-01-10 03:00
Stadium: Estadio Azteca Round: 1
Referee: Alejandro Funk Villafane Home Manager: Santiago Hernan Solari Poggio Away Manager: Leonel Rocco
Head to Head
| Mexico Liga MX | 2020/08/30 00:00 | Atletico San Luis v Club America | W | 1-2 |
| Mexico Liga MX | 2019/10/30 01:00 | Atletico San Luis v Club America | W | 0-1 |
| Mexico Cup | 2019/01/31 03:00 | Atletico San Luis v Club America | L | 2-0 |
| Mexico Cup | 2019/01/24 03:00 | Club America v Atletico San Luis | W | 1-0 |
Home History
| CONCACAF Champions Cup | 2020/12/20 03:30 | Los Angeles FC v Club America | L | 3-1 |
| CONCACAF Champions Cup | 2020/12/17 01:00 | Atlanta United v Club America | L | 1-0 |
| Mexico Liga MX | 2020/11/29 03:06 | Club America v Chivas Guadalajara | L | 1-2 |
| Mexico Liga MX | 2020/11/26 03:06 | Chivas Guadalajara v Club America | L | 1-0 |
| Mexico Liga MX | 2020/11/07 03:30 | Juarez FC v Club America | D | 1-1 |
| Mexico Liga MX | 2020/11/01 23:30 | Club America v Tigres UANL | W | 3-1 |
| Mexico Liga MX | 2020/10/25 02:00 | Club America v Atlas | W | 1-0 |
| Mexico Liga MX | 2020/10/20 02:00 | Leon v Club America | L | 3-2 |
Away History
| Mexico Liga MX | 2020/11/07 01:30 | Puebla v Atletico San Luis | L | 1-0 |
| Mexico Liga MX | 2020/10/30 03:00 | Atletico San Luis v Mazatlan FC | L | 0-5 |
| Mexico Liga MX | 2020/10/26 01:06 | Santos Laguna v Atletico San Luis | L | 2-1 |
| Mexico Liga MX | 2020/10/16 02:00 | Atletico San Luis v Queretaro | W | 2-1 |
| Mexico Liga MX | 2020/10/04 00:00 | Tigres UANL v Atletico San Luis | L | 3-0 |
| Mexico Liga MX | 2020/09/27 22:00 | Atletico San Luis v Leon | L | 0-2 |
| Mexico Liga MX | 2020/09/21 00:00 | Atletico San Luis v Monterrey | L | 1-2 |
| Mexico Liga MX | 2020/09/13 17:00 | Unam Pumas v Atletico San Luis | L | 3-0 |