[3] Puebla 0-0 Unam Pumas [13] 2021-04-24 00:30
Stadium: Estadio Cuauhtemoc Round: 16
Referee: Oscar Mejia Garcia Home Manager: Nicolas Larcamon Away Manager: Andres Lillini
Head to Head
| Mexico Liga MX | 2020/09/05 22:00 | Unam Pumas v Puebla | L | 4-1 |
| Mexico Liga MX | 2019/11/02 01:00 | Puebla v Unam Pumas | D | 1-1 |
| Mexico Liga MX | 2019/03/16 03:00 | Puebla v Unam Pumas | W | 1-0 |
| Mexico Liga MX | 2018/09/30 17:00 | Unam Pumas v Puebla | D | 2-2 |
| Mexico Liga MX | 2018/04/15 17:00 | Unam Pumas v Puebla | L | 4-2 |
| Mexico Liga MX | 2017/10/28 00:00 | Puebla v Unam Pumas | W | 3-0 |
| Mexico Liga MX | 2017/05/07 17:00 | Unam Pumas v Puebla | W | 0-1 |
| Mexico Liga MX | 2016/11/21 00:00 | Puebla v Unam Pumas | L | 0-3 |
| Mexico Liga MX | 2016/01/24 18:00 | Unam Pumas v Puebla | W | 0-1 |
| Mexico Liga MX | 2015/08/09 22:00 | Puebla v Unam Pumas | W | 3-2 |
| Mexico Liga MX | 2015/03/22 18:00 | Unam Pumas v Puebla | L | 2-1 |
| Mexico Liga MX | 2014/10/02 00:00 | Puebla v Unam Pumas | L | 1-2 |