[2] River Plate 1-2 San Lorenzo [5] 2021-04-25 21:00
Stadium: Estadio Monumental Antonio Vespucio Liberti Round: 11
Referee: Fernando Echenique Home Manager: Marcelo Gallardo Away Manager: Diego Dabove
Head to Head
| Argentina Superliga | 2019/12/09 00:45 | River Plate v San Lorenzo | L | 0-1 |
| Argentina Superliga | 2018/09/01 23:00 | San Lorenzo v River Plate | D | 1-1 |
| Argentina Superliga | 2018/05/15 00:15 | River Plate v San Lorenzo | W | 2-0 |
| Argentina Superliga | 2017/06/04 17:00 | San Lorenzo v River Plate | L | 2-1 |
| Argentina Liga Profesional | 2016/05/07 20:45 | San Lorenzo v River Plate | L | 2-1 |
| Argentina Torneo De Verano | 2016/01/27 01:10 | River Plate v San Lorenzo | W | 3-2 |
| Argentina Liga Profesional | 2015/04/05 19:00 | River Plate v San Lorenzo | W | 1-0 |
| Recopa Sudamericana | 2015/02/12 00:00 | San Lorenzo v River Plate | W | 0-1 |
| Recopa Sudamericana | 2015/02/07 00:00 | River Plate v San Lorenzo | W | 1-0 |
| Argentina Liga Profesional | 2014/09/01 00:30 | San Lorenzo v River Plate | W | 1-3 |
| Argentina Superliga | 2014/05/25 00:15 | San Lorenzo v River Plate | W | 0-1 |