[4] Cerro Porteno 2-2 Guairena FC [9] 2021-02-21 21:30
Stadium: General Pablo Rojas Round: 4
Referee: Alipio Colman Home Manager: Francisco Arce Away Manager: Troadio Daniel Duarte
Head to Head
| Paraguay Division Profesional | 2020/11/07 21:15 | Guairena FC v Cerro Porteno | D | 1-1 |
| Paraguay Division Profesional | 2020/08/26 21:00 | Guairena FC v Cerro Porteno | W | 1-2 |
| Paraguay Division Profesional | 2020/02/15 22:15 | Cerro Porteno v Guairena FC | D | 2-2 |