Northern Iowa 10-16 Iowa State 2021-09-04 20:30
Stadium: Jack Trice Stadium Round: 1
Home Manager: Matt Campbell Away Manager: Mark Farley
Head to Head
| NCAAF | 2019/08/31 16:00 | Northern Iowa v Iowa State | L | 26-29 |
| NCAAF | 2017/09/03 00:00 | Northern Iowa v Iowa State | L | 24-42 |
| NCAAF | 2016/09/04 00:00 | Iowa State v Northern Iowa | W | 20-25 |
| NCAAF | 2015/09/06 00:00 | Iowa State v Northern Iowa | L | 31-7 |
| NCAAF | 2011/09/03 12:00 | Iowa State v Northern Iowa | L | 20-19 |
| NCAAF | 2010/09/25 12:00 | Iowa State v Northern Iowa | L | 27-0 |
| NCAAF | 2007/09/08 12:00 | Iowa State v Northern Iowa | W | 13-24 |
| NCAAF | 2006/09/30 12:00 | Iowa State v Northern Iowa | L | 28-27 |
| NCAAF | 2004/09/04 12:00 | Iowa State v Northern Iowa | L | 23-0 |
| NCAAF | 2003/08/30 12:00 | Iowa State v Northern Iowa | L | 17-10 |
| NCAAF | 2001/09/08 12:00 | Iowa State v Northern Iowa | L | 45-0 |