Northern Iowa 10-16 Iowa State 2021-09-04 20:30
Stadium: Jack Trice Stadium Round: 1
Home Manager: Matt Campbell Away Manager: Mark Farley
Head to Head
| NCAAF | 2019/08/31 16:00 | Northern Iowa v Iowa State | L | 26-29 |
| NCAAF | 2017/09/03 00:00 | Northern Iowa v Iowa State | L | 24-42 |
| NCAAF | 2016/09/04 00:00 | Iowa State v Northern Iowa | W | 20-25 |
| NCAAF | 2015/09/06 00:00 | Iowa State v Northern Iowa | L | 31-7 |
| NCAAF | 2011/09/03 12:00 | Iowa State v Northern Iowa | L | 20-19 |
| NCAAF | 2010/09/25 12:00 | Iowa State v Northern Iowa | L | 27-0 |
| NCAAF | 2007/09/08 12:00 | Iowa State v Northern Iowa | W | 13-24 |
| NCAAF | 2006/09/30 12:00 | Iowa State v Northern Iowa | L | 28-27 |
Home History
| NCAAF | 2021/04/10 21:00 | North Dakota State v Northern Iowa | L | 23-20 |
| NCAAF | 2021/03/27 16:00 | Northern Iowa v Western Illinois | W | 34-20 |
| NCAAF | 2021/03/20 21:00 | Missouri St v Northern Iowa | L | 13-6 |
| NCAAF | 2021/03/13 18:00 | Northern Iowa v SO Illinois | L | 16-17 |
| NCAAF | 2021/03/06 22:00 | Illinois State v Northern Iowa | W | 10-20 |
| NCAAF | 2021/02/27 17:00 | Northern Iowa v Youngstown State | W | 21-0 |
| NCAAF | 2021/02/20 01:00 | South Dakota State v Northern Iowa | L | 24-20 |
| NCAAF | 2019/12/14 00:00 | Northern Iowa v James Madison | L | 0-17 |
Away History
| NCAAF | 2021/01/02 21:00 | Oregon v Iowa State | W | 17-34 |
| NCAAF | 2020/12/19 17:00 | Oklahoma v Iowa State | L | 27-21 |
| NCAAF | 2020/12/05 20:30 | West Virginia v Iowa State | W | 6-42 |
| NCAAF | 2020/11/27 17:00 | Iowa State v Texas | W | 23-20 |
| NCAAF | 2020/11/21 21:00 | Kansas State v Iowa State | W | 0-45 |
| NCAAF | 2020/11/08 00:00 | Baylor v Iowa State | W | 31-38 |
| NCAAF | 2020/10/31 16:00 | Iowa State v Kansas | W | 52-22 |
| NCAAF | 2020/10/24 19:30 | Iowa State v Oklahoma State | L | 21-24 |