Missouri State 16-23 Oklahoma State 2021-09-04 23:00
Stadium: Boone Pickens Stadium Round: 1
Home Manager: Mike Gundy Away Manager: Bobby Petrino
Head to Head
| NCAAF | 2018/08/31 00:00 | Missouri St v Oklahoma State | L | 17-58 |
| NCAAF | 2014/09/06 19:30 | Oklahoma State v Missouri St | L | 40-23 |
| NCAAF | 2008/09/13 12:00 | Oklahoma State v Missouri St | L | 57-13 |
| NCAAF | 2006/09/02 12:00 | Oklahoma State v Missouri St | L | 52-10 |
| NCAAF | 2003/09/13 12:00 | Oklahoma State v Missouri St | L | 42-3 |