[3] Puebla 1-0 Santos Laguna [5] 2021-05-24 00:00
Stadium: Estadio Cuauhtemoc Round: 2
Referee: Fernando Guerrero Ramirez Home Manager: Nicolas Larcamon Away Manager: Guillermo Almada
Head to Head
| Mexico Liga MX | 2021/05/21 02:00 | Santos Laguna v Puebla | L | 3-0 |
| Mexico Liga MX | 2021/05/03 00:06 | Santos Laguna v Puebla | D | 0-0 |
| Mexico Liga MX | 2020/10/03 00:30 | Puebla v Santos Laguna | L | 0-2 |
| Mexico Liga MX | 2020/02/08 03:00 | Puebla v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2019/08/11 23:45 | Santos Laguna v Puebla | L | 4-1 |
| Mexico Liga MX | 2019/01/19 03:00 | Puebla v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2018/08/05 23:00 | Santos Laguna v Puebla | L | 2-0 |
| Mexico Liga MX | 2018/03/17 01:00 | Puebla v Santos Laguna | L | 0-1 |
| Mexico Liga MX | 2017/10/01 23:30 | Santos Laguna v Puebla | D | 0-0 |
| Mexico Liga MX | 2017/01/30 00:00 | Santos Laguna v Puebla | L | 2-0 |
| Mexico Liga MX | 2016/08/07 23:00 | Puebla v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2016/02/28 01:00 | Santos Laguna v Puebla | D | 1-1 |
| Mexico Liga MX | 2015/09/13 22:00 | Puebla v Santos Laguna | L | 0-1 |
| Mexico Liga MX | 2015/05/10 01:30 | Santos Laguna v Puebla | D | 2-2 |
| Mexico Liga MX | 2014/11/22 23:00 | Puebla v Santos Laguna | D | 3-3 |
| Mexico Cup | 2014/11/05 03:00 | Santos Laguna v Puebla | L | 4-2 |