[15] Unam Pumas 0-3 Santos Laguna [9] 2021-11-05 01:00
Stadium: Estadio Olimpico Universitario Round: 11
Referee: Adonai Escobedo Gonzalez Home Manager: Andres Lillini Away Manager: Guillermo Almada
Head to Head
| Mexico Liga MX | 2021/03/05 03:00 | Unam Pumas v Santos Laguna | W | 1-0 |
| Mexico Liga MX | 2020/09/10 02:06 | Santos Laguna v Unam Pumas | W | 1-2 |
| Mexico Liga MX | 2020/02/02 03:00 | Santos Laguna v Unam Pumas | D | 1-1 |
| Mexico Cup | 2020/01/30 01:00 | Unam Pumas v Santos Laguna | W | 2-1 |
| Mexico Cup | 2020/01/23 03:00 | Santos Laguna v Unam Pumas | L | 4-2 |
| Mexico Liga MX | 2019/09/29 17:00 | Unam Pumas v Santos Laguna | W | 2-0 |
| Mexico Liga MX | 2019/05/05 23:06 | Santos Laguna v Unam Pumas | L | 5-2 |
| Mexico Liga MX | 2018/11/25 18:00 | Unam Pumas v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2018/04/22 23:00 | Santos Laguna v Unam Pumas | W | 1-2 |
| Mexico Liga MX | 2017/11/05 18:00 | Unam Pumas v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2017/03/05 18:00 | Unam Pumas v Santos Laguna | W | 2-1 |
| Mexico Liga MX | 2016/09/18 23:00 | Santos Laguna v Unam Pumas | L | 3-1 |
| Club Friendly List | 2016/07/02 23:00 | Unam Pumas v Santos Laguna | L | 1-2 |
| Mexico Liga MX | 2016/02/21 18:00 | Unam Pumas v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2015/08/29 02:30 | Santos Laguna v Unam Pumas | W | 3-4 |
| Mexico Liga MX | 2015/04/19 17:00 | Unam Pumas v Santos Laguna | W | 1-0 |
| Mexico Liga MX | 2014/10/25 02:30 | Santos Laguna v Unam Pumas | D | 1-1 |