[15] Unam Pumas 0-3 Santos Laguna [9] 2021-11-05 01:00
Stadium: Estadio Olimpico Universitario Round: 11
Referee: Adonai Escobedo Gonzalez Home Manager: Andres Lillini Away Manager: Guillermo Almada
Head to Head
| Mexico Liga MX | 2021/03/05 03:00 | Unam Pumas v Santos Laguna | W | 1-0 |
| Mexico Liga MX | 2020/09/10 02:06 | Santos Laguna v Unam Pumas | W | 1-2 |
| Mexico Liga MX | 2020/02/02 03:00 | Santos Laguna v Unam Pumas | D | 1-1 |
| Mexico Cup | 2020/01/30 01:00 | Unam Pumas v Santos Laguna | W | 2-1 |
| Mexico Cup | 2020/01/23 03:00 | Santos Laguna v Unam Pumas | L | 4-2 |
| Mexico Liga MX | 2019/09/29 17:00 | Unam Pumas v Santos Laguna | W | 2-0 |
| Mexico Liga MX | 2019/05/05 23:06 | Santos Laguna v Unam Pumas | L | 5-2 |
| Mexico Liga MX | 2018/11/25 18:00 | Unam Pumas v Santos Laguna | D | 1-1 |
Home History
| Mexico Liga MX | 2021/10/31 00:06 | Pachuca v Unam Pumas | D | 1-1 |
| Mexico Liga MX | 2021/10/24 17:00 | Unam Pumas v Tijuana | W | 3-1 |
| Mexico Liga MX | 2021/10/21 00:00 | Leon v Unam Pumas | W | 1-2 |
| Mexico Liga MX | 2021/10/17 17:00 | Unam Pumas v Juarez FC | W | 1-0 |
| World Club Friendlies | 2021/10/09 01:30 | Club America v Unam Pumas | W | 0-1 |
| Mexico Liga MX | 2021/10/03 22:00 | Club America v Unam Pumas | L | 2-0 |
| Mexico Liga MX | 2021/09/26 00:00 | Tigres UANL v Unam Pumas | D | 0-0 |
| Mexico Liga MX | 2021/09/19 02:00 | Mazatlan FC v Unam Pumas | D | 2-2 |
Away History
| Mexico Liga MX | 2021/10/30 22:00 | Queretaro v Santos Laguna | W | 2-3 |
| Mexico Liga MX | 2021/10/25 00:06 | Santos Laguna v Toluca | D | 2-2 |
| Mexico Liga MX | 2021/10/20 00:05 | Club America v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2021/10/17 00:00 | Pachuca v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlan FC | W | 1-0 |
| Mexico Liga MX | 2021/09/27 00:06 | Santos Laguna v Monterrey | L | 1-2 |
| Mexico Liga MX | 2021/09/20 02:06 | Santos Laguna v Puebla | D | 1-1 |
| Leagues Cup | 2021/09/15 02:00 | Seattle Sounders v Santos Laguna | L | 1-0 |