Southern Illinois 42-41 South Dakota State 2021-10-09 19:00
Stadium: Dana J. Dykhouse Stadium Round: 1
Home Manager: John Stiegelmeier Away Manager: Nick Hill
Head to Head
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | L | 26-31 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | L | 44-3 |
| NCAAF | 2019/10/05 19:00 | SO Illinois v South Dakota State | L | 10-28 |
| NCAAF FCS | 2018/11/10 19:00 | South Dakota State v SO Illinois | L | 57-38 |
| NCAAF | 2017/10/07 23:00 | South Dakota State v SO Illinois | L | 49-14 |