Stadium: Dana J. Dykhouse Stadium Round: 1
Home Manager: John Stiegelmeier Away Manager: Nick Hill
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | L | 26-31 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | L | 44-3 |
| NCAAF | 2019/10/05 19:00 | SO Illinois v South Dakota State | L | 10-28 |
| NCAAF FCS | 2018/11/10 19:00 | South Dakota State v SO Illinois | L | 57-38 |
| NCAAF | 2017/10/07 23:00 | South Dakota State v SO Illinois | L | 49-14 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | W | 31-30 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | W | 17-35 |
| NCAAF | 2021/09/18 23:00 | Dayton v SO Illinois | W | 3-55 |
| NCAAF | 2021/09/11 23:00 | SO Illinois v Kansas State | L | 23-31 |
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | W | 47-21 |
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | L | 26-31 |
| NCAAF | 2021/04/24 20:00 | SO Illinois v Weber State | W | 34-31 |
| NCAAF | 2021/04/17 17:00 | SE Louisiana v SO Illinois | W | 48-55 |
| NCAAF | 2021/10/02 23:00 | Utah Tech v South Dakota State | W | 7-55 |
| NCAAF | 2021/09/25 17:00 | South Dakota State v Indiana State | W | 44-0 |
| NCAAF | 2021/09/11 23:00 | South Dakota State v Lindenwood | W | 52-7 |
| NCAAF | 2021/09/04 01:00 | South Dakota State v Colorado State | W | 42-23 |
| NCAAF | 2021/05/16 18:00 | Sam Houston State v South Dakota State | L | 23-21 |
| NCAAF | 2021/05/08 16:00 | Delaware v South Dakota State | W | 3-33 |
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | W | 26-31 |
| NCAAF | 2021/04/24 19:00 | Holy Cross v South Dakota State | W | 3-31 |