[16] Atletico San Luis 2-1 Puebla [2] 2022-03-13 23:00
Stadium: Alfonso Lastras Ramirez Round: 10
Referee: Luis Enrique Santander Aguirre Home Manager: Andre Jardine Away Manager: Nicolas Larcamon
Head to Head
| Mexico Liga MX | 2021/09/11 00:00 | Puebla v Atletico San Luis | D | 2-2 |
| Mexico Liga MX | 2021/04/17 22:00 | Atletico San Luis v Puebla | L | 1-4 |
| Mexico Liga MX | 2020/11/07 01:30 | Puebla v Atletico San Luis | L | 1-0 |
| Mexico Liga MX | 2020/03/14 23:00 | Atletico San Luis v Puebla | L | 0-1 |
| Mexico Liga MX | 2019/09/14 00:00 | Puebla v Atletico San Luis | W | 1-3 |