[3] Cobreloa 1-0 Club Deportes Santa Cruz [14] 2022-06-02 19:00
Stadium: Municipal de Calama Round: 5
Head to Head
| Chile Primera B | 2021/11/06 23:30 | Club Deportes Santa Cruz v Cobreloa | D | 2-2 |
| Chile Primera B | 2021/08/08 15:00 | Cobreloa v Club Deportes Santa Cruz | L | 0-1 |
| Chile Primera B | 2020/12/10 13:00 | Club Deportes Santa Cruz v Cobreloa | L | 4-1 |
| Chile Primera B | 2020/09/06 15:00 | Cobreloa v Club Deportes Santa Cruz | L | 0-1 |
| Chile Primera B | 2019/06/02 19:00 | Club Deportes Santa Cruz v Cobreloa | L | 1-0 |