[2] Oriente Petrolero 1-2 Real Santa Cruz [8] 2022-05-14 20:00
Stadium: Estadio Ramon Tahuichi Aguilera Round: 15
Head to Head
| Bolivia Apertura | 2022/04/02 19:00 | Real Santa Cruz v Oriente Petrolero | L | 2-1 |
| Bolivia Apertura | 2021/12/05 00:30 | Oriente Petrolero v Real Santa Cruz | W | 2-0 |
| Bolivia Apertura | 2021/08/07 19:00 | Real Santa Cruz v Oriente Petrolero | D | 0-0 |
| Bolivia Apertura | 2020/12/16 23:30 | Oriente Petrolero v Real Santa Cruz | W | 3-2 |
| Bolivia Apertura | 2020/02/16 19:00 | Real Santa Cruz v Oriente Petrolero | W | 1-5 |