[7] Kentucky 19-22 Mississippi [9] 2022-10-01 16:00
Stadium: Vaught-Hemingway Stadium Round: 1
Home Manager: Lane Kiffin Away Manager: Mark Stoops
Head to Head
| NCAAF | 2020/10/03 20:00 | Mississippi v Kentucky | L | 42-41 |
| NCAAF | 2017/11/04 20:00 | Mississippi v Kentucky | L | 37-34 |
| NCAAF | 2011/11/05 12:00 | Kentucky v Mississippi | W | 30-13 |
| NCAAF | 2010/10/02 12:00 | Mississippi v Kentucky | L | 42-35 |
| NCAAF | 2006/09/16 12:00 | Kentucky v Mississippi | W | 31-14 |
| NCAAF | 2005/10/22 12:00 | Mississippi v Kentucky | L | 13-7 |
| NCAAF | 2001/09/29 12:00 | Kentucky v Mississippi | L | 31-42 |
| NCAAF | 2000/09/30 12:00 | Mississippi v Kentucky | L | 35-17 |