[10] Iowa State 14-20 Oklahoma State [4] 2022-11-12 20:30
Stadium: Boone Pickens Stadium Round: 1
Home Manager: Mike Gundy Away Manager: Matt Campbell
Head to Head
| NCAAF | 2021/10/23 19:30 | Oklahoma State v Iowa State | W | 21-24 |
| NCAAF | 2020/10/24 19:30 | Iowa State v Oklahoma State | L | 21-24 |
| NCAAF | 2019/10/26 19:30 | Oklahoma State v Iowa State | L | 34-27 |
| NCAAF | 2018/10/06 19:30 | Iowa State v Oklahoma State | W | 48-42 |
| NCAAF | 2017/11/11 17:00 | Oklahoma State v Iowa State | L | 49-42 |
| NCAAF | 2016/10/08 19:30 | Iowa State v Oklahoma State | L | 31-38 |
| NCAAF | 2015/11/14 20:30 | Iowa State v Oklahoma State | L | 31-35 |
| NCAAF | 2014/10/04 16:00 | Oklahoma State v Iowa State | L | 37-20 |
| NCAAF | 2012/10/20 12:00 | Oklahoma State v Iowa State | L | 31-10 |
| NCAAF | 2011/11/18 12:00 | Iowa State v Oklahoma State | W | 37-31 |
| NCAAF | 2009/11/07 12:00 | Iowa State v Oklahoma State | L | 8-34 |
| NCAAF | 2008/11/01 12:00 | Oklahoma State v Iowa State | L | 59-17 |
| NCAAF | 2005/10/22 12:00 | Iowa State v Oklahoma State | W | 37-10 |
| NCAAF | 2004/10/02 12:00 | Oklahoma State v Iowa State | L | 36-7 |
| NCAAF | 2001/10/20 12:00 | Iowa State v Oklahoma State | W | 28-14 |
| NCAAF | 2000/10/14 12:00 | Oklahoma State v Iowa State | W | 26-33 |