[17] Mazatlan FC 1-2 Santos Laguna [9] 2023-01-21 03:00
Stadium: Estadio de Mazatlan Round: 3
Referee: Cesar Arturo Ramos Palazuelos Home Manager: Gabriel Caballero Away Manager: Eduardo Fentanes
Head to Head
| Club Friendly List | 2022/12/24 03:00 | Mazatlan FC v Santos Laguna | L | 2-3 |
| Mexico Liga MX | 2022/10/02 23:05 | Santos Laguna v Mazatlan FC | L | 3-0 |
| Mexico Liga MX | 2022/04/20 02:00 | Mazatlan FC v Santos Laguna | W | 1-0 |
| Club Friendly List | 2022/01/29 02:00 | Mazatlan FC v Santos Laguna | W | 2-1 |
| Mexico Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlan FC | L | 1-0 |
| Mexico Liga MX | 2021/01/23 03:30 | Mazatlan FC v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2020/11/09 01:06 | Santos Laguna v Mazatlan FC | L | 4-0 |
| Mexico Liga MX | 2016/07/31 23:00 | Santos Laguna v Mazatlan FC | W | 2-4 |
| Mexico Liga MX | 2016/05/01 01:30 | Mazatlan FC v Santos Laguna | W | 3-2 |
| Mexico Liga MX | 2015/11/07 03:30 | Santos Laguna v Mazatlan FC | W | 2-3 |
| Mexico Liga MX | 2015/04/04 01:30 | Mazatlan FC v Santos Laguna | L | 0-1 |
| Mexico Liga MX | 2014/10/05 01:00 | Santos Laguna v Mazatlan FC | D | 2-2 |