Stadium: O'Brien Stadium Round: 1
Home Manager: Chris Wilkerson Away Manager: Brock Spack
| NCAAF | 2022/09/17 23:30 | Eastern Illinois v Illinois State | W | 7-35 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | W | 31-24 |
| NCAAF | 2019/09/14 19:00 | Illinois State v Eastern Illinois | W | 21-3 |
| NCAAF | 2018/09/08 23:30 | Eastern Illinois v Illinois State | W | 10-48 |
| NCAAF | 2017/09/16 19:00 | Eastern Illinois v Illinois State | W | 13-44 |