Stadium: O'Brien Stadium Round: 1
Home Manager: Chris Wilkerson Away Manager: Brock Spack
| NCAAF | 2022/09/17 23:30 | Eastern Illinois v Illinois State | W | 7-35 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | W | 31-24 |
| NCAAF | 2019/09/14 19:00 | Illinois State v Eastern Illinois | W | 21-3 |
| NCAAF | 2018/09/08 23:30 | Eastern Illinois v Illinois State | W | 10-48 |
| NCAAF | 2017/09/16 19:00 | Eastern Illinois v Illinois State | W | 13-44 |
| NCAAF | 2023/09/09 20:00 | Illinois State v Western Illinois | W | 34-18 |
| NCAAF | 2023/09/02 17:00 | Dayton v Illinois State | W | 0-41 |
| NCAAF | 2022/11/19 17:00 | Western Illinois v Illinois State | W | 13-20 |
| NCAAF | 2022/11/12 20:00 | Illinois State v South Dakota State | L | 7-31 |
| NCAAF | 2022/11/05 19:00 | Youngstown State v Illinois State | L | 19-17 |
| NCAAF | 2022/10/29 19:30 | Illinois State v North Dakota State | L | 7-24 |
| NCAAF | 2022/10/22 17:00 | Illinois State v Indiana State | W | 27-21 |
| NCAAF | 2022/10/15 19:00 | South Dakota v Illinois State | W | 10-12 |
| NCAAF | 2023/09/09 18:00 | Eastern Illinois v Bowling Green | L | 15-38 |
| NCAAF | 2023/08/31 22:00 | Eastern Illinois v Indiana State | W | 27-0 |
| NCAAF | 2022/11/19 20:00 | Eastern Illinois v Tennessee Martin | L | 31-34 |
| NCAAF | 2022/11/12 20:00 | SE Missouri St v Eastern Illinois | L | 31-7 |
| NCAAF | 2022/11/06 00:00 | Eastern Illinois v McNeese State | L | 15-29 |
| NCAAF | 2022/10/29 19:00 | Tennessee Tech v Eastern Illinois | L | 20-17 |
| NCAAF | 2022/10/22 19:00 | Eastern Illinois v Tennessee State | L | 17-37 |
| NCAAF | 2022/10/15 19:00 | Lindenwood v Eastern Illinois | L | 37-34 |